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Treatment with Remodulin
Why Remodulin?
Because you’ve got more to do. And you want to be able to do more of the things that make you who you are.
If you and your doctor aren’t seeing the improvements you had hoped for in your exercise ability and PAH symptoms, it may be time to consider a prostacyclin treatment like Remodulin. In as little as 3 months, Remodulin may help increase your exercise capacity and lessen PAH symptoms (such as shortness of breath and fatigue), which may help you get back to doing more of the things you love.
As the #1 most prescribed pump therapy for PAH, Remodulin has been trusted by patients and their doctors for more than 20 years.
Remember, you are not alone. United Therapeutics was founded to support people with PAH, like you, and remains committed to improving your experience with pump therapy. With Remodulin, you have access to our social communities, support programs, and other resources that may be helpful as you navigate your treatment journey.
How will Remodulin change my day-to-day life?
Incorporating pump therapy into your life might feel intimidating at first, but it is possible and may get easier over time with the help of your healthcare team. Some people say that pump therapy allows them to think less about treatment because they don’t have to remember to take medicine during the day—the pump does all the work.
Remember, you have healthcare providers, Specialty Pharmacy, friends and family, and connections from PAH support groups who can help support you every step of the way. This team can help you with all aspects of day-to-day management of PAH and your treatment, including tips and advice to help you get used to having a pump. By staying with your therapy, you may be able to reduce your symptoms so you are able to do more in your daily life.
There are many things you can do to help make Remodulin a part of your daily life.
How is Remodulin administered?
Remodulin is delivered through a pump system, giving you continuous delivery of medicine 24 hours a day, 7 days a week. So you can be confident you’re getting the medicine you need.
Administering Remodulin may take some getting used to, but just take it step-by-step until you feel comfortable with your new routine.
Remodulin has different routes of administration:
Subcutaneous (SC) Administration:
Remodulin is delivered to the body via a very thin tube (cannula) not much thicker than a thread that is inserted just beneath the skin.
Learn MoreIntravenous (IV) Administration:
Remodulin is delivered directly into the bloodstream via a narrow flexible tube called a catheter that is placed directly into a vein in your upper chest area.
Learn More
Your doctor will recommend the best delivery option for you.
United Therapeutics is committed to continuously improving the patient experience. Ask your doctor about the different pump options available for the delivery of Remodulin.
Learn more about taking the next step with Remodulin and different administration options in the Remodulin Patient Brochure.
How does Remodulin work?
In PAH, the body does not produce enough prostacyclin, a natural substance that keeps blood vessels open and working properly.
Blood vessel flow in the lungs
Remodulin acts like natural prostacyclin in your body to help keep the blood vessels in your lungs open. This may make it easier for your heart to pump blood through your lungs and help lessen your symptoms of PAH. Because Remodulin is delivered continuously, you can feel confident you are getting the prostacyclin your body needs throughout the day.
What are the side effects with Remodulin?
- With SC infusion of Remodulin, most people experience infusion site pain and infusion site reaction (redness, swelling, and rash)
- With IV infusion of Remodulin delivered through an external pump, there is a risk of bloodstream infections, arm swelling, tingling sensations, bruising, and pain
- The most common side effects seen with either SC or IV Remodulin are headache, diarrhea, nausea, rash, jaw pain, widening of the blood vessels (vasodilatation), and swelling from fluid retention (edema). These are not all the possible side effects of Remodulin
It is not unusual to experience side effects when taking Remodulin. Be sure to talk to your doctor about what to expect from treatment with Remodulin so you are prepared.
Together, you and your doctor can create a proactive plan to help treat side effects. There are medicines and methods your doctor can recommend to help manage side effects that occur with Remodulin and help you stay on therapy.
Learn about side effectsUnderstanding Your Heart
In this video, you’ll meet Beth, a real patient living with PAH. Beth explains her discussions with her doctor about the impact PAH was having on her heart, and why her doctor chose Remodulin.
View helpful information about living with Remodulin
- Understand how pump therapy works with Remodulin
- Learn about how Remodulin is different and the benefits and risks associated with it
- Find information on living with PAH and what to expect from Remodulin
It can be helpful to talk to other patients about what tools they used and to find a network of support during treatment.
Remodulin® (treprostinil) Injection
Important Safety Information for Remodulin
Before you take Remodulin, tell your healthcare provider if you:
- Have other medical conditions or take other medicines that may affect your use of Remodulin by increasing the risk of side effects or decreasing the drug’s effectiveness.
- Have liver or kidney problems. Your Remodulin dose may need to be adjusted if you have liver problems.
- Have low blood pressure or bleeding problems.
- Are taking gemfibrozil (for high cholesterol), rifampin (for infection) or other drugs that affect liver enzymes. Your doctor may need to adjust your Remodulin dosage.
- Are pregnant, breastfeeding, or planning to become pregnant. It is not known if Remodulin will harm your unborn baby or if Remodulin passes into your breast milk.
What are the serious side effects of Remodulin?
- Continuous intravenous (IV) infusions of Remodulin delivered using an external infusion pump, with a tube placed in a central vein within the chest, are associated with the risk of blood stream infections and sepsis, which may be fatal. Therefore, continuous subcutaneous (SC) infusion delivered just beneath the skin is the preferred type of delivery.
- Worsening of PAH symptoms. Do not stop taking or greatly reduce your Remodulin dose without consulting your doctor.
- Low blood pressure (symptomatic hypotension). If you have low blood pressure or are taking drugs that lower your blood pressure, the risk of low blood pressure is increased.
- Bleeding problems. Remodulin may increase the risk of bleeding in people who take blood thinners (anticoagulants).
What are the possible side effects of Remodulin?
- In clinical studies of SC infusion of Remodulin, most people experienced infusion site pain and infusion site reaction (redness, swelling, and rash). These symptoms were sometimes severe and sometimes required treatment with narcotics or discontinuation of Remodulin.
- IV infusion of Remodulin delivered through an external pump has been associated with the risk of blood stream infections, arm swelling, tingling sensations, bruising, and pain.
- The most common side effects seen with either SC or IV Remodulin were headache, diarrhea, nausea, rash, jaw pain, widening of the blood vessels (vasodilatation), and swelling from fluid retention (edema). These are not all the possible side effects of Remodulin. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.
You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.
The risk information provided here is not comprehensive.
What is Remodulin?
Remodulin is a prescription medication used to treat adults with pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. Remodulin can reduce symptoms associated with exercise. Remodulin was studied mainly in patients with NYHA Functional Class II-IV symptoms. It is not known if Remodulin is safe and effective in children.
In people with PAH who need to switch from epoprostenol, Remodulin is approved to slow the worsening of symptoms.
REMISIconMAY2021
To learn more about Remodulin, talk with your healthcare provider. Please see Full Prescribing Information at www.remodulin.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).
To learn more about Remodulin, talk with your healthcare provider. Please see Full Prescribing Information at www.remodulin.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).
PAH=pulmonary arterial hypertension; WHO=World Health Organization.
Remodulin® (treprostinil) Injection
Important Safety Information for Remodulin
Before you take Remodulin, tell your healthcare provider if you:
- Have other medical conditions or take other medicines that may affect your use of Remodulin by increasing the risk of side effects or decreasing the drug’s effectiveness.
- Have liver or kidney problems. Your Remodulin dose may need to be adjusted if you have liver problems.
- Have low blood pressure or bleeding problems.
- Are taking gemfibrozil (for high cholesterol), rifampin (for infection) or other drugs that affect liver enzymes. Your doctor may need to adjust your Remodulin dosage.
- Are pregnant, breastfeeding, or planning to become pregnant. It is not known if Remodulin will harm your unborn baby or if Remodulin passes into your breast milk.
What are the serious side effects of Remodulin?
- Continuous intravenous (IV) infusions of Remodulin delivered using an external infusion pump, with a tube placed in a central vein within the chest, are associated with the risk of blood stream infections and sepsis, which may be fatal. Therefore, continuous subcutaneous (SC) infusion delivered just beneath the skin is the preferred type of delivery.
- Worsening of PAH symptoms. Do not stop taking or greatly reduce your Remodulin dose without consulting your doctor.
- Low blood pressure (symptomatic hypotension). If you have low blood pressure or are taking drugs that lower your blood pressure, the risk of low blood pressure is increased.
- Bleeding problems. Remodulin may increase the risk of bleeding in people who take blood thinners (anticoagulants).
What are the possible side effects of Remodulin?
- In clinical studies of SC infusion of Remodulin, most people experienced infusion site pain and infusion site reaction (redness, swelling, and rash). These symptoms were sometimes severe and sometimes required treatment with narcotics or discontinuation of Remodulin.
- IV infusion of Remodulin delivered through an external pump has been associated with the risk of blood stream infections, arm swelling, tingling sensations, bruising, and pain.
- The most common side effects seen with either SC or IV Remodulin were headache, diarrhea, nausea, rash, jaw pain, widening of the blood vessels (vasodilatation), and swelling from fluid retention (edema). These are not all the possible side effects of Remodulin. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.
The risk information provided here is not comprehensive.
What is Remodulin?
Remodulin is a prescription medication used to treat adults with pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. Remodulin can reduce symptoms associated with exercise. Remodulin was studied mainly in patients with NYHA Functional Class II-IV symptoms. It is not known if Remodulin is safe and effective in children.
In people with PAH who need to switch from epoprostenol, Remodulin is approved to slow the worsening of symptoms.
REMISIconMAY2021
To learn more about Remodulin, talk with your healthcare provider. Please see Full Prescribing Information at www.remodulin.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).
PAH=pulmonary arterial hypertension; WHO=World Health Organization.